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4(1H)-Quinazolinone, 1-[3-(trifluoromethyl)phenyl]-, also known as 1-(3-trifluoromethylphenyl)quinazolin-4(3H)-one, is a chemical compound with the molecular formula C10H5F3N2O. It is a derivative of quinazolinone, a heterocyclic compound with a quinazoline core, and features a trifluoromethyl group attached to the phenyl ring. 4(1H)-Quinazolinone, 1-[3-(trifluoromethyl)phenyl]- is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and properties. It is typically synthesized through various chemical reactions, such as condensation or cyclization, and can be further functionalized to create a range of compounds with different biological activities.

1683-36-9

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1683-36-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1683-36-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,8 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1683-36:
(6*1)+(5*6)+(4*8)+(3*3)+(2*3)+(1*6)=89
89 % 10 = 9
So 1683-36-9 is a valid CAS Registry Number.

1683-36-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-trifluoromethyl-phenyl)-1H-quinazolin-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1683-36-9 SDS

1683-36-9Downstream Products

1683-36-9Relevant academic research and scientific papers

Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1

Monteillier, Aymeric,Loucif, Alexandre,Omoto, Kiyoyuki,Stevens, Edward B.,Vicente, Sergio L.,Saintot, Pierre-Philippe,Cao, Lishuang,Pryde, David C.

, p. 4919 - 4924 (2016)

TRESK (Twik RElated Spinal cord K+channel) is a member of the Twin Pore Domain potassium channel (K2P) family responsible for regulating neuronal excitability in dorsal root ganglion (DRG) and trigeminal (TG) neurons, peripheral neurons involved in pain transmission. As channel opening causes an outward K+current responsible for cell hyperpolarisation, TRESK represents a potentially interesting target for pain treatment. However, as no crystal structure exists for this protein, the mechanisms involved in the opening action of its ligands are still poorly understood, making the development of new potent and selective openers challenging. In this work we present a structure activity relationship (SAR) of the known TRESK opener flufenamic acid (FFA) and some derivatives, investigating the functional effects of chemical modifications to build a TRESK homology model to support the biological results. A plausible binding mode is proposed, providing the first predictive hypothesis of a human TRESK opener binding site.

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