16834-21-2

Upstream product

• 3156-37-4 (E)-1-bromo-4-(2-nitrovinyl)benzene 
• 108-94-1 cyclohexanone 
• 3156-37-4 4-bromo-β-nitrostyrene 

Relevant academic research and scientific papers

Silica-supported pyrrolidine-triazole, an insoluble, recyclable organocatalyst for the enantioselective Michael addition of ketones to nitroalkenes

A highly efficient, silica-supported organocatalyst for the Michael addition of ketones to nitroalkenes is successfully developed. A 1,2,3-triazole ring, constructed via a click 1,3-dipolar cycloaddition, plays a dual role of grafting the chiral pyrrolidi

Synthesis of a New N-Diaminophosphoryl-N'-[(2S)-2-pyrrolidinylmethyl]thiourea as a Chiral Organocatalyst for the Stereoselective Michael Addition of Cyclohexanone to Nitrostyrenes and Chalcones – Application in Cascade Processes for the Synthesis of Polyc

A highly diastereoselective and enantioselective Michael addition of enolizable ketones such as cyclohexanone and acetophenone to a variety of substituted trans-?-nitrostyrenes and chalcones was catalyzed by a novel chiral and unsymmetrical thiourea as or

Prolinal dithioacetals: Highly efficient organocatalysts for the direct nitro-Michael additions in both organic and aqueous media

Some novel prolinal dithioacetal derivatives have been synthesized and applied as the organocatalysts for the direct Michael addition of ketones and aldehydes to nitroalkenes. High enantioselectivities and diastereoselectivities have been obtained in both

Asymmetric conjugate additions of carbonyl compounds to nitroalkenes under solvent-free conditions using fluorous diaminomethylenemalononitrile organocatalyst

The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products with excellent enantioselectivities under solvent-free conditions.

Synthesis of chiral γ - nitrophenol compound method (by machine translation)

The invention provides a method for synthesizing chiral γ - nitrophenol compound method, said method comprising the following steps: the chiral catalyst, cocatalyst, organic solvent A mixing, stirring condition point pen (iii) ketone compound shown in formula (iv) indicated by the nitroolefin compound, for 10 - 40 °C stirring for 6 - 18 the H, formula (v) compound of formula; to the of formula (v) is added in the compounds of the copper bromide, in an organic solvent in the B, in the 90 - 120 °C stirring reaction under 0.8 h - 6 h, formula (i) shown γ - nitrophenol compound of; the advantage of this invention is characterized in that: the chiral nitro alkanes substituted phenol compound has wide application space, synthetic method of this invention, the operation is simple, mild reaction conditions, show good response characteristic, the reaction yield is high, good selectivity. (by machine translation)

Asymmetric conjugate additions of carbonyl compounds to nitroalkenes under solvent-free conditions using fluorous diaminomethylenemalononitrile organocatalyst

The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products w

Pyrrolidine modified PANF catalyst for asymmetric Michael addition of ketones to nitrostyrenes in aqueous phase

Three chiral pyrrolidine functionalized polyacrylonitrile fiber catalysts have been designed, prepared, and evaluated for their catalytic performance in asymmetric Michael addition of ketones to nitrostyrenes in water. With the optimized catalysts and conditions in hand, their reaction scope for nitrostyrenes was explored. Then the fiber catalysts were further applied to a packed-bed reactor for continuous-flow Michael addition. Based on the fact that organic solvent can inhibit the catalytic activity, a novel microenvironment catalytic mechanism is proposed.

Organocatalytic asymmetric Michael addition of aldehydes and ketones to nitroalkenes catalyzed by adamantoyl L-prolinamide

A series of adamantoyl l-prolinamides have been synthesized. These compounds have been found to be highly efficient organocatalysts for the Michael addition of aldehydes and ketones to nitroalkenes. Under the optimized reaction conditions, the correspondi

Pyrrolidine-diaminomethylenemalononitrile organocatalyst for Michael additions of carbonyl compounds to nitroalkenes under solvent-free conditions

The novel pyrrolidine-diaminomethylenemalononitrile organocatalyst 7 promotes the asymmetric conjugate addition of a carbonyl compound to a nitroalkene to afford the corresponding adduct in high yield with up to 99% ee, under solvent-free conditions.

Syntheses of chiral ferrocenophanes and their application to asymmetric catalysis

N-Substituted 2-aza-[3]-ferrocenophanes were easily synthesized from 1,1′-ferrocenedicarbaldehyde and aliphatic amines in high yields. One of the ferrocenophanes served as a ligand for the copper-catalyzed oxidative coupling of 2-naphthol derivatives to give the products in good yields with up to 92% ee, and it also efficiently catalyzed the asymmetric Michael addition reaction as an organocatalyst.