16836-47-8Relevant academic research and scientific papers
Sesquiterpenoids
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, (2016/01/16)
The invention provides novel compounds and compositions for inhibiting IKKα/β, including treating disorders associated with IKKα/β activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure shown above.
Total syntheses of ainsliadimer B and gochnatiolides A and B
Xia, Dongliang,Du, Yu,Yi, Zhi,Song, Hao,Qin, Yong
, p. 4423 - 4427 (2013/05/09)
Oh my goch: The total syntheses of ainsliadimer B and gochnatiolides A and B from α-santonin have been accomplished in 25 steps with approximately 1 % overall yield. A Diels-Alder reaction of natural dehydrozaluzanin C with a monomeric guaianolide derivative allows stereoselective assembly of a dimeric gochnatiolide-type skeleton with the required stereochemistry and preinstalled functionalities for the synthesis of dimeric ainsliadimer B and gochnatiolides A and B (see scheme). Copyright
Dehydrozaluzanin C: A potent plant growth regulator with potential use as a natural herbicide template
Macias, Francisco A.,Galindo, Juan C.G.,Molinillo, Jose M.G.,Castellano, Diego
, p. 165 - 171 (2007/10/03)
The natural product dehydrozaluzanin C (former DHZ) is a sesquiterpene lactone obtained from different weeds of the Compositae family. Its potential as a plant growth regulator has been evaluated by using a phytotoxic allelopathic bioassay, where the commercial herbicide Logran is used as internal reference. The evaluation is made based on their effects on germination and growth over several dicotyledon and monocotyledon species. The activity was tested in the range of 1000-0.001 μM. In almost all cases, DHZ was more active than the internal reference at 1000 μM, and its activity fell below the level of the internal reference at 100 μM. These results confirm DHZ as a potent plant growth regulator and good candidate for the development of new herbicide models. (C) 2000 Elsevier Science Ltd.
Developing new herbicide models from allelochemicals
Macias, Francisco A.,Galindo, Juan C. G.,Molinillo, Jose M. G.,Castellano, Diego,Velasco, Paul F.,Chinchilla, David
, p. 662 - 665 (2007/10/03)
Plants contain allelochemicals which are their own defence systems and can act as herbicides. Selected examples of guaianolides and heliannuols, which are sesquiterpenes, are discussed in the context of their potential use as natural herbicide templates.
DEHYDROCOSTUSLACTONE AND PLANT GROWTH ACTIVITY OF DERIVED GUAIANOLIDES
Kalsi, P. S.,Kaur, Gurdeep,Sharma, Sunila,Talwar, K. K.
, p. 2855 - 2862 (2007/10/02)
Key Word Index-Saussurea lappa; Compositae; root promoters; sesquiterpene lactone; guaianolide; dehydrocostuslactone; estafiatin; isozaluzanin C; isodehydrocostuslactone.The stereostructures of two new guaianolides, isodehydrocostuslactone and isozaluzanin C, isolated previously from Saussurea lappa, have been confirmed by their correlation with dehydrocostuslactone.Twenty new derivatives have been synthesized from these guaianolides and these have been tested as plant growth regulators.The conjugated lactones which have an exocyclic methylene group at C-4, conjugated with a C-3 ketone, show distinct enhancement in their root-forming potential, as compared with their 3-deoxy derivatives.Of further significance is the fact that these ketones display maximum activity only at lower concentrations.Other compounds show the expected structure-biological activity relationships displayed in general by guaianolides.However, the presence of an epoxide at the C-3, C-4 position does not affect the biological activity, which is indeed the case when the epoxide group occupies the C-4, C-14 position in guaianolides.The major biological parameter studied was rooting in-stem cuttings of Phaseolus aureus.
