168418-66-4

Upstream product

• 5609-09-6 trans 3-hepten-2-one 
• 477937-56-7 (2-methyl-1,3-dioxan-2-yl)-2-phthalimidopentane 
• 477937-58-9 (8S,10S)-8-ethoxycarbonyl-10-propyl-1,5-dioxa-9-azaspiro[5.5]undecane 
• 477937-40-9 (7S,9S)-7-ethoxycarbonyl-9-propyl-1,4-dithia-8-azaspiro[5.4]decane 
• 477937-52-3 N-4-oxoheptan-2-yl-phthalimide 
• 477937-55-6 (+)-(S)-2-(2-aminopentyl)-2-methyl-1,3-dioxane 
• 501-53-1 benzyl chloroformate 
• 477937-41-0 (2S,6S)-ethyl N-benzyloxycarbonyl-6-propyl-2-piperidinecarboxylate 
• 168418-67-5 (S)-N-(benzyloxycarbonyl)-1-propyl-5-hexenylamine 

Downstream Products

• 168418-70-0 (2S,6S)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-1-propenyl)-6-propylpiperidine 
• 168418-69-7 (2S,6S)-2-Formyl-6-propyl-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of C-6 substituted pipecolic acid derivatives. Formal synthesis of (+)-indolizidine 167B and (+)-indolizidine 209D

C-6 Substituted pipecolic acid derivatives were synthesized through two different pathways. The synthetic potential of each route was demonstrated by the formal synthesis of indolizidine Dendrobates alkaloids.

ASYMMETRIC SYNTHESIS OF OF INDOLIZIDINES 167B AND 223AB

The total synthesis of (+)-indolizidine 167B (1) and the formal synthesis (-)-indolizidine 223AB (2) starting with l- and d-norvaline-derived cis-hydroxymethyl-6-propylpiperidines (3 and ent-3), respectively, are described.