16850-99-0Relevant articles and documents
ISOXAZOLES-MEDIATED SYNTHESIS OF GEIPARVARIN AND DIHYDROGEIPARVARIN
Baraldi, P. G.,Barco, A.,Benetti, S.,Casolari, A.,Manfredini, S.,et al.
, p. 1267 - 1272 (2007/10/02)
A new synthesis of geiparvarin 1 and its dihydroderivative 2, two naturally occuring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described.The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.