16851-98-2Relevant academic research and scientific papers
Synthesis of 3′,4′-Diaryl-4′H-spiro[indoline-3,5′-[1′,2′,4′]oxadiazol]-2-ones via DMAP-catalyzed Domino Reactions and Their Antibacterial Activity
Shi, Guanghao,He, Xinwei,Shang, Yongjia,Xiang, Liwei,Yang, Cheng,Han, Guang,Du, Bing
, p. 901 - 909 (2016/09/20)
A convenient and metal-free DMAP-catalyzed domino reaction of isatins, arylamines and hydroximoyl chlorides has been developed to achieve 1,3-dipolar cycloaddition of imines into aryl nitrile oxides at ambient temperature. In this one-pot transformation,
"On water" synthesis of spiro-indoles via Schiff bases
Panda, Siva S.,Jain, Subhash C.
experimental part, p. 1187 - 1194 (2012/09/25)
A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic am
Synthesis of 1′-aryl-2′-(2-oxoindolin-3-yl)spiro[indoline-3, 5′-pyrroline]-2,3′-dione via one-pot reaction of arylamines, acetone, and isatins
Sun, Yan,Sun, Jing,Yan, Chao-Guo
supporting information; experimental part, p. 3647 - 3649 (2012/09/22)
An efficient synthetic method for 1′-aryl-2′-(2-oxoindolin-3- yl)spiro[indoline-3,5′-pyrroline]-2,3′-diones was successfully developed via the one-pot domino reaction of arylamines, acetone, and isatins in acetic acid. The reaction mechanism involved the
Microwave induced dry-media synthesis of spiro[indole-thiazolidinones/ thiazinones] as potential antifungal and antitubercular agents and study of their reactions
Dandia, Anshu,Singh, Ruby,Arya, Kapil
, p. 551 - 564 (2007/10/03)
A series of new spiro[3H-indole-3,2′-thiazolidine]-2,4′(1H.)- diones (IV) and spiro[3H-indole-3,2′-tetrahydro-1,3-thiazine]-2, 4′(1H)-diones (V) have been synthesized in 85-93% yield by the one-pot environmentally benign microwave induced technique involving the cyclocondensation of 3-arylimino-2H-indol-2-ones (III) with thioacids viz. mercapto aceticacid (a) / 3-mercapto propionicacid (b) using montmorillonite KSF as inorganic solid support. Intermediates (III) were synthesized in situ by the reaction of indole-2,3-diones (I) and substituted anilines (II). The spiro compounds have been further subjected to solvent-free acetylation, aminoalkylation and thiation under microwave irradiation using solid supports. The synthesized compounds have been screened in vitro for antifungal activity against Rhizoctonia solani, Fusarium oxysporum, and Collectotrichum capsici, and antitubercular acivity against Mycobacterium tuberculosis.
Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives
Sridhar, Seshaiah Krishnan,Saravanan, Muniyandy,Ramesh, Atmakuru
, p. 615 - 625 (2007/10/03)
Schiff bases and hydrazones of substituted isatins (1-28) were prepared by reacting isatin and aromatic primary amines/hydrazines. A new series of the corresponding N-Mannich base (29-35) was synthesised by reacting them with formaldehyde and diphenyl ami
