168540-62-3

Upstream product

• 492-41-1 (1R,2S)-norephedrine 
• 16251-45-9 (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one 
• 646-07-1 4-Methylpentanoic acid 

Downstream Products

• 244177-70-6 (4S,5R)-3-((2S,3R)-2-isobutyl-3-hydroxypent-4-enoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-on 
• 1026016-83-0 ((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one) 
• 1228458-05-6 (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one 
• 1384186-23-5 C₅₂H₈₆N₂O₈Si₂ 
• 1228458-10-3 (2R,3S,11bR)-2-hydroxy-3-isobutyl-9,10-dimethoxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-α]isoquinolin-4(11bH)-one 
• 1384186-29-1 C₄₀H₅₈N₂O₈ 
• 1384186-25-7 C₂₉H₃₂F₃NO₆ 
• 1384186-26-8 C₂₉H₃₂F₃NO₆ 
• 1384186-22-4 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide 
• 1384186-21-3 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(4,5-dimethoxy-2-vinylphenethyl)-2-isobutylpent-4-enamide 
• 318957-53-8 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutyl]allyloxy}dimethylsilanyloxy)-2-isobutylpent-4-enethioic acid S-benzyl ester 
• 318957-55-0 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutyl]allyloxy}dimethylsilanyloxy)-2-isobutylpent-4-enethioic acid S-benzyl ester 
• 318957-54-9 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutyl]allyloxy}dimethylsilanyloxy)-2-isobutylpent-4-enethioic acid S-benzyl ester 
• 244177-82-0 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutyl]allyloxy}dimethylsilanyloxy)-2-isobutylpent-4-enethioic acid S-benzyl ester 

Relevant academic research and scientific papers

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine

A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.

A synthetic library of cell-permeable molecules

Small molecules that induce or stabilize the association of macromolecules have proven to be useful effectors of a wide variety of biological processes. To date, all examples of such chemical inducers of dimerization have involved known ligands to well-ch

SULFOXIMINE AND SULDODIIMINE MATRIX METALLOPROTEINASE INHIBITORS

Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, STR1 wherein: R 1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl carbonyl, lower-alkyoxyalkyl, aralkyl and heteroaralkyl;X is NH or O;R 2 is selected from the group consisting of hydrogen, lower-alkyl and aralkyl;R 3 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, aralkyl and heteroaralkyl; andR 4 is selected from the group consisting of lower alkyl, aralkyl and--CH(R 5)--C(O)NH 2, wherein R 5 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, hydroxymethyl, 1-hydroxyethyl, mercapto lower-alkyl, and methylthio lower-alkyl;useful for modulating physiological functions or treating diseases and disease conditions associated with matrix metalloproteinase modulation.