16858-19-8Relevant academic research and scientific papers
Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists
Negoro, Kenji,Yonetoku, Yasuhiro,Maruyama, Tatsuya,Yoshida, Shigeru,Takeuchi, Makoto,Ohta, Mitsuaki
experimental part, p. 2369 - 2375 (2012/05/05)
Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.
Pyrimidine derivatives and drugs
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, (2008/06/13)
The object of the present invention is to obtain new class of compounds which have improving effect on learning and memory disorders with good selectivity in central nervous system and little side effects and then to provide a good medicine for treatment
3-AMINO-2-HYDROXYPROPYL OF PYRIMIDIN-4-ONE USEFUL AS ANTIHYPERTENSIVE, CARDIOSELECTIVE, ANTIARRHYTHMIC, AND ANTIANGINAL AGENTS
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, (2008/06/13)
The novel compounds of this invention and their pharmaceutically acceptable salts exhibit cardioselective β-adrenergic blocking activity, with a direct relaxing effect on the β. sub.2-adrenergic receptors and are useful as antihypertensive, cardioprotecti
