168682-53-9

Basic information

• Product Name: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
• Synonyms: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-;Ezatiostat;Terrapin 199;(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester;Ezatiostat, >=98%;Ezatiostat (TER199)
• CAS NO: 168682-53-9
• Molecular Formula: C27H35N3O6S
• Molecular Weight: 529.6483
• EINECS: -0
• Mol File: 168682-53-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 749.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12?+-.0.46(Predicted)
• CAS DataBase Reference: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-(168682-53-9)
• EPA Substance Registry System: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-(168682-53-9)

Safety Data

• Hazardous Substances Data: 168682-53-9(Hazardous Substances Data)

Usage

Description

Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)is a complex organic compound with a specific stereochemistry. It is a derivative of the naturally occurring tripeptide glutathione, featuring a unique structure that includes a phenylmethyl group and a diethyl ester functional group. Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)is characterized by its chiral center at the 2R configuration, which plays a crucial role in its biological activity and potential applications.

Uses

Used in Pharmaceutical Industry:
Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)is used as a therapeutic agent for targeting glutathione S-transferase pi 1-1 (GSTP1-1). It acts as a selective inhibitor of GSTP1-1, which is the most prevalent isozyme of Glutathione S-transferases (GST) in nonhepatic tissues. By inhibiting GSTP1-1, this compound can potentially disrupt the catalytic activity of this enzyme, thereby affecting cellular processes and offering therapeutic benefits in various conditions.
Used in Research Applications:
In the field of research, Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)serves as a valuable tool for studying the role of GSTP1-1 in cellular processes and its interaction with other proteins, such as JNK1. Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)can be used to investigate the effects of GSTP1-1 inhibition on cellular signaling pathways and to explore the potential of targeting this enzyme for therapeutic purposes.
Used in Drug Development:
Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)is also utilized in the development of novel drugs targeting GSTP1-1. Its unique structure and selectivity for GSTP1-1 make it a promising candidate for the design of new therapeutic agents that can potentially treat various diseases and conditions by modulating the activity of this enzyme.