1687855-43-1

Basic information

• Product Name: methyl4-aminoisoquinoline-8-carboxylate
• Synonyms: methyl4-aminoisoquinoline-8-carboxylate
• CAS NO: 1687855-43-1
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.2093
• Mol File: 1687855-43-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl4-aminoisoquinoline-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl4-aminoisoquinoline-8-carboxylate(1687855-43-1)
• EPA Substance Registry System: methyl4-aminoisoquinoline-8-carboxylate(1687855-43-1)

Safety Data

• Hazardous Substances Data: 1687855-43-1(Hazardous Substances Data)

Usage

General Description

Methyl 4-aminoisoquinoline-8-carboxylate is a chemical compound with the molecular formula C12H11N3O2. It is a derivative of the aminoisoquinoline family and is commonly used as a building block for the synthesis of pharmaceutical compounds and heterocyclic molecules. This chemical is known for its potential biological activities and has been studied for its antimicrobial, anticancer, and antiviral properties. Methyl 4-aminoisoquinoline-8-carboxylate is a valuable intermediate for the production of a wide range of drugs and has potential applications in the pharmaceutical and medical industries.

Upstream product

• 850858-56-9 8-isoquinolinecarboxylic acid methyl ester 
• 63927-22-0 8-bromo-isoquinoline 

Relevant articles and documents

4 - amino quinoline - 8 - carboxylic acid methyl ester

The invention provides a synthesis method of 4-aminoisoquinoline-8-methyl formate. According to the synthesis method, 8-bromoisoquinoline reacts with carbon monoxide in methanol in the presence of palladium acetate to generate 8-isoquinoline methyl formate; 8-isoquinoline methyl formate reacts with N-bromosuccinimide in acetic acid to generate 4-bromoisoqunoline-8-methyl formate; the compound reacts with tert-butyl carbamate in the presence of the palladium acetate and cesium carbonate to generate amino protected 4-t-butoxycarbonylaminoisoquinoline-8-methyl formate, and finally, the protecting group of 4-t-butoxycarbonylaminoisoquinoline-8-methyl formate is removed in a mixed solvent of hydrochloric acid and methanol to obtain 4-aminoisoquinoline-8-methyl formate. The synthesis method of 4-aminoisoquinoline-8-methyl formate is good in selectivity, high in total yield (71%), convenient to operate, simple in after-treatment and suitable for large-scale production.