16879-60-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2'-bismethylthio-5,5'-bipyrimidine is used as an intermediate in the synthesis of pharmaceutical drugs, particularly for the development of antiviral and antineoplastic agents. Its unique structure and properties contribute to the creation of effective medications targeting viral infections and cancerous cells.
Used in Corrosion Inhibition:
2,2'-bismethylthio-5,5'-bipyrimidine is studied for its potential use as a corrosion inhibitor. It can be applied in various industries to protect metal surfaces from corrosion, extending the lifespan of equipment and infrastructure.
Used in Photoinduced Electron Transfer Sensor:
2,2'-bismethylthio-5,5'-bipyrimidine has been explored for its potential as a photoinduced electron transfer sensor. This application can be utilized in the development of advanced sensor technologies for detecting and monitoring various chemical and environmental parameters.

Upstream product

• 103-64-0 bromostyrene 
• 120717-37-5 2-methylthio-5-tributylstannylpyrimidine 
• 147716-06-1 1-benzenesulfonyl-1H-pyrrole-3-carbonyl chloride 

Relevant academic research and scientific papers

Preparation of 5-(Pyrrolylcarbonyl)- and 5-(Imidazolylcarbonyl)-pyrimidines

2-Methylthio-5-(pyrrolylcarbonyl)-pyrimidines have been prepared from 1-methyl-2-tributylstannylpyrrole and 2-methylthiopyrimidine-5-carbonyl chloride by Pd-catalysis.Triphenylarsine was superior to triphenylphosphine as a ligand in the reaction.The reaction with phosphine ligands proceeded well when the polarization of the reactants was reversed as in the reaction between pyrrolecarbonyl chlorides and 2-methylthio-5-tributylstannylpyrimidine. 1-Methyl-5-tributylstannylimidazole has been prepared in a one-pot reaction from 1-methylimidazole in 91percent yield.

Syntheses of 5-Alkenylpyrimidines by Organotin Reactions

5-Stannylpyrimidines can be prepared from the corresponding bromides by lithiation at -95 deg C and quenching with tributylstannyl chloride.The 5-stannyl-pyrimidine is used in Pd-catalyzed coupling reactions with vinyl bromides.The opposite reaction sequence, i.e.Pd-catalyzed coupling between 5-halopyrimidines and vinyltin derivatives, is also described.Alternatively, the 5-vinylpyrimidines have been obtained by dehydrohalogenation with cesium fluoride and by a modified Wittig reaction. 2-Methylthiopyrimidines are transformed into the 2-methoxy derivatives or 2-pyrimidinones using chloramine-T (CAT) in a simple one-pot synthesis.