168828-15-7 Usage
Uses
Used in Pharmaceutical Synthesis:
(S)-3-CBZ-AMINO-BUTYLAMINE is used as a chiral building block for the synthesis of various pharmaceuticals and organic molecules. Its unique structure and properties enable the development of enantiomerically pure compounds, which are essential for the production of effective and safe medications.
Used in Organic Synthesis:
(S)-3-CBZ-AMINO-BUTYLAMINE is used as a chiral resolving agent in organic synthesis. Its ability to form stable complexes with metal ions makes it a valuable reagent in coordination chemistry and organometallic synthesis, facilitating the synthesis of complex organic molecules with high selectivity and yield.
Used in Synthesis of Biologically Active Compounds:
(S)-3-CBZ-AMINO-BUTYLAMINE is used as a precursor for the synthesis of biologically active compounds. Its unique structure and properties allow for the development of novel compounds with potential applications in various fields, such as medicine, agriculture, and materials science.
Used in Chiral Separation Techniques:
(S)-3-CBZ-AMINO-BUTYLAMINE has been studied for its potential use in chiral separation techniques. Its ability to form stable complexes with metal ions can be utilized to selectively separate enantiomers, which is crucial for the production of enantiomerically pure compounds in various industries, including pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 168828-15-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,8,2 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 168828-15:
(8*1)+(7*6)+(6*8)+(5*8)+(4*2)+(3*8)+(2*1)+(1*5)=177
177 % 10 = 7
So 168828-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O2/c1-10(7-8-13)14-12(15)16-9-11-5-3-2-4-6-11/h2-6,10H,7-9,13H2,1H3,(H,14,15)/t10-/m0/s1
168828-15-7Relevant articles and documents
Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?
Terzi?, Natasa,Konstantinovi?, Jelena,Tot, Miklo?,Burojevi?, Jovana,Djurkovi?-Djakovi?, Olgica,Srbljanovi?, Jelena,?tajner, Tijana,Verbi?, Tatjana,Zlatovi?, Mario,Machado, Marta,Albuquerque, Inês S.,Prudêncio, Miguel,Sciotti, Richard J.,Pecic, Stevan,D'Alessandro, Sarah,Taramelli, Donatella,?olaja, Bogdan A.
supporting information, p. 264 - 281 (2016/01/29)
The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.
