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168834-43-3

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168834-43-3 Usage

Uses

2-Amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzenemethanol is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

Check Digit Verification of cas no

The CAS Registry Mumber 168834-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,8,3 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 168834-43:
(8*1)+(7*6)+(6*8)+(5*8)+(4*3)+(3*4)+(2*4)+(1*3)=173
173 % 10 = 3
So 168834-43-3 is a valid CAS Registry Number.

168834-43-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-amino-3-chloro-α-cyclopropylethynyl-α-(trifluoromethyl)benzyl alcohol

1.2 Other means of identification

Product number -
Other names 2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:168834-43-3 SDS

168834-43-3Relevant articles and documents

Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis

Zheng, Yu,Tan, Yuqi,Harms, Klaus,Marsch, Michael,Riedel, Radostan,Zhang, Lilu,Meggers, Eric

supporting information, p. 4322 - 4325 (2017/04/06)

A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%).

Electrophile-driven copper-catalyzed one-pot synthesis of 3-halogen quinoline derivatives

Cheng, Jie,Zhai, Hong,Bai, Jun,Tang, Jun,Lv, Ling,Sun, Bei

supporting information, p. 4044 - 4046 (2015/02/02)

A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization-halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent.

Alkynylation of carbonyl compounds with terminal acetylenes promoted by ZnCl2 and Et3N: Simple, mild and efficient preparation of propargylic alcohols

Jiang, Biao,Si, Yu-Gui

, p. 8323 - 8325 (2007/10/03)

A mild and efficient addition of terminal acetylenes to carbonyl compounds in the presence of ZnCl2 and Et3N gives propargylic alcohols in good to high yields.

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