168902-79-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Inden-1-amine, 2,3-dihydro-5-methylis used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications. 1H-INDEN-1-AMINE, 2,3-DIHYDRO-5-METHYL-'s reactivity and functional groups enable the formation of diverse chemical entities, contributing to the discovery of novel medicinal agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Inden-1-amine, 2,3-dihydro-5-methylserves as an essential building block for the creation of new agrochemicals. Its properties make it suitable for the development of pesticides, herbicides, and other agricultural chemicals that can improve crop yield and protect plants from pests and diseases.
Used in Dye and Pigment Industry:
1H-Inden-1-amine, 2,3-dihydro-5-methylis utilized as an intermediate in the production of dyes and pigments. Its chemical structure allows for the synthesis of a wide range of colorants with various shades and properties. These dyes and pigments find applications in various industries, including textiles, plastics, inks, and coatings.
Used in Organic Compounds Synthesis:
1H-INDEN-1-AMINE, 2,3-DIHYDRO-5-METHYLis also used as a versatile intermediate in the synthesis of other organic compounds. Its reactivity and functional groups make it a valuable building block for the creation of new chemical entities with potential applications in various fields, such as materials science, chemical research, and specialty chemicals.

InChI:InChI=1/C10H13N/c1-7-2-4-9-8(6-7)3-5-10(9)11/h2,4,6,10H,3,5,11H2,1H3

Upstream product

• 4593-38-8 5-methylindan-1-one 

Relevant academic research and scientific papers

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.