168907-76-4

Upstream product

• 40877-09-6 4-chloro-1-(4-chlorophenyl)butan-1-one 
• 168907-65-1 1-(4-chlorophenyl)-4-iodobutan-1-one 
• 168907-67-3 2-(4-chlorophenyl)-2-(3-iodopropyl)-1,3-dioxolane 
• 168907-72-0 2-(4-chlorophenyl)-2-<3-(1-trityl-2-imidazolyl)propyl>-1,3-dioxolane 

Relevant academic research and scientific papers

Synthesis of 1-Halophenyl 4-(2-Imidazolyl)-1-butanones and 5-(2-Imidazolyl)-1-pentanones and Their Ketalization with Glycerol

An alternate synthesis of 1-(2,4-dichlorophenyl)-4-(2-imidazolyl)-1-butanones 5d is presented after 1-[(dimethylamino)methyl- and 1-metbyl]-2-lithioimidazole failed to be substituted satisfactorily by 2-(2,4-dichlorophenyl)-2-(3-iodopropyl)-1,3-dioxolane

Synthesis of Aryl 3-(2-Imidazolyl)propyl Ketones.

The approach to the title compounds was via lithiation-substitution of N-methyl or N-(triphenylmethyl)imidazole by some iodo ketals. 4-Chloro-4'-halobutyrophenones (halo = F, Cl, Br) were converted by sodium iodide to the corresponding aliphatic iodides which were subsequently ketalized with ethylene glycol to provide the corresponding iodo ketals.Lithiation of either 1-methyl- or 1-(triphenylmethyl)imidazole with n-butyllithium generated the corresponding 2-lithioimidazoles, in situ, which were then reacted with these iodo ketals to form the corresponding C-2 substitute d imidazoles.Dilute aqueous acid hydrolysis released the ketone from the ketal.For N-triphenylmethyl protected imidazoles, the triphenylmethyl group was also hydrolyzed to give triphenylmethanol and 3-(2-imidazolyl)propyl 4-haloaryl ketones.These N-unsubstituted imidazolyl ketones can be alkylated independently with triphenylmethyl chloride to form the corresponding N-triphenylmethyl imidazole derivatives.