16892-03-8

Basic information

• Product Name: (7S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
• Synonyms: (7S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one;(S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one;Speciosine;(S)-7-((2-hydroxybenzyl)(methyl)amino)-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• CAS NO: 16892-03-8
• Molecular Formula: C₂₈H₃₁NO₆
• Molecular Weight: 477.55
• Mol File: 16892-03-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 720.4°C at 760 mmHg
• Flash Point: 389.5°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.9E-21mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: (7S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (7S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one(16892-03-8)
• EPA Substance Registry System: (7S)-6,7-Dihydro-7-[[(2-hydroxyphenyl)methyl]methylamino]-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one(16892-03-8)

Safety Data

• Hazardous Substances Data: 16892-03-8(Hazardous Substances Data)

Usage

Description

An alkaloid found in Colchicum speciosum Stev., the base yields prismatic yellow crystals from a mixture of C6H6 and Me2CO. It has [α]20D- 21.2° (c 1.752, CHCI3). Four methoxyl groups and one phenolic hydroxyl group are present, the structure given above having been confirmed by synthesis.

References

Kise1ev.,J. Gen. Chem., USSR, 26,3218 (1956) Synthesis: Barker et ai., Chem. Commun., 390 (1967)

InChI:InChI=1/C28H31NO6/c1-29(16-18-8-6-7-9-22(18)30)21-12-10-17-14-25(33-3)27(34-4)28(35-5)26(17)19-11-13-24(32-2)23(31)15-20(19)21/h6-9,11,13-15,21,30H,10,12,16H2,1-5H3/t21-/m0/s1

Upstream product

• 142735-49-7 Acetylspecioseine 
• 186581-53-3 diazomethane 
• 142735-47-5 Specioseine 

Downstream Products

• 142735-51-1 Diacetylspecioseine 
• 142735-49-7 Acetylspecioseine 

Relevant articles and documents

ALKALOID SPECIOSEINE FROM Colchicum speciosum

The fraction of weak bases from Colchicum speciosum Stev. (family Liliaceae) has yielded a new compound - specioseine.The structure of 10-demethylspeciosine has been established for this base by chemical and spectral methods.