168965-49-9

Basic information

• Product Name: [2-(4-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester
• Synonyms: [2-(4-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 168965-49-9
• Molecular Weight: 420.636
• Mol File: 168965-49-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [2-(4-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester(168965-49-9)
• EPA Substance Registry System: [2-(4-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester(168965-49-9)

Safety Data

• Hazardous Substances Data: 168965-49-9(Hazardous Substances Data)

Upstream product

• 60902-45-6 nonyltriphenylphosphonium bromide 
• 623-27-8 terephthalaldehyde, 
• 51359-78-5 4-(bromomethyl)benzaldehyde 
• 52010-97-6 4-(hydroxylmethyl)benzaldehyde 
• 155526-48-0 2-Acetylamino-2-[4-((E)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester 
• 168965-45-5 2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester 
• 168965-43-3 ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4-formyl-2-nitrophenyl)propanoate 
• 168965-46-6 {2-[4-((E)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester 
• 763059-86-5 2-Amino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester 
• 174363-83-8 [2-(2-Amino-4-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester 
• 155526-65-1 4-(bromomethyl)-3-nitrobenzaldehyde 

Downstream Products

• 169106-26-7 2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid benzyl ester 

Relevant articles and documents

Synthesis, conformation, and biological activity of teleocidin mimics, benzolactams. A clarification of the conformational flexibility problem in structure-activity studies of teleocidins

Tumor-promoter teleocidins and their active congeners (indolactams) are known to exist in an equilibrium between at least two conformational states in solution, the twist and sofa form, due to cis-trans isomerization of the amide bond and the steric effects of substituents on the nine-membered lactam ring. Benzolactam-Vs, in which the indole ring of indolactams is replaced with a benzene ring, were designed and synthesized in an attempt to reproduce the active conformation of teleocidins. Among these benzolactams, eight-membered lactams (benzolactam-V8) can only exist in the twist form, and 9- and 10-membered lactams (benzolactam-V9 and -V10) exist exclusively in the sofa form in solution. The stronger biological activity of benzolactam-V-8-310 than that of indolactam-V (IL-V) and the inactivity of benzolactam-V-9-310 for differentiation inducing activity of HL-60 clearly indicated that the twist form is close to the active conformation of teleocidins.