168975-94-8Relevant academic research and scientific papers
Derivatisation of an anti-cancer cationic antimicrobial peptide and its complexation to platinum(II)
Parker, James P.,Devocelle, Marc,Marmion, Celine J.
, p. 1628 - 1635 (2013)
This work focuses on the cationic antimicrobial peptide (CAP) DP18L with its known propensity to target and selectively kill cancer cells. DP18L was derivatised to dap-DP18L where dap is 2,3-diaminopropionic acid. Dap facilitated binding to PtII/sup
Michael addition reactions of acetoacetates and malonates with acrylates in water under strongly alkaline conditions
Iwamura, Michiko,Gotoh, Yuka,Hashimoto, Tomoyuki,Sakurai, Reiko
, p. 6275 - 6277 (2005)
Michael addition reactions of acetoacetates and malonates with acrylates in a 5 M KOH aqueous solution without using any other catalysts are described. When they are either tert-butyl or benzyl esters, the reaction proceeded very rapidly to afford moderate to high yields of the corresponding bis-Michael adducts that are unexpectedly stable under these conditions.
Synthesis of water-soluble, multiple functionalizable dendrons for the conversion of large dendrimers or other molecular objects into potential drug carriers
Mueller, Stephan,Schlueter, A. Dieter
, p. 5589 - 5610 (2007/10/03)
The synthesis of dendrons and dendrimers which carry OEG chains and bidentate ligands and/or fluorescence tags is described. The orthogonally protected functional groups of the dendrons allow modification of the substitution pattern and attachment to larg
PREPARATION OF HOMOLOGOUS PYRAZOLONEDICARBOXYLATES
Makarevic, Janja,Skaric, Vinko
, p. 1207 - 1218 (2007/10/02)
Homologous disodium pyrazolonedicarboxylates (8, 16f and 16g) as possible protectors of cis-DDP induced nephrotoxicity, have been prepared by the reaction of hydrazine with di-t-butyl ethyl β-keto triesters (5b, 13b and 13c) and subsequent hydrolysis of f
