168984-32-5Relevant academic research and scientific papers
Synthesis of 2-oxaadamantane and 1-aryl-2-oxaadamantanes
Benneche, Tore,Tius, Marcus A.
, p. 3150 - 3151 (2016/07/06)
The direct reduction of 1-hydroxy-2-oxaadamantanes derivatives to give 2-oxaadamantanes was unsuccessful. 2-Oxaadamantanes could, however, be prepared from 1-hydroxy-2-oxaadamantes by a ring-opening reaction followed by reduction and subsequent ring-closu
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
Duque, Maria D.,Camps, Pelayo,Profire, Lenuta,Montaner, Silvia,Vazquez, Santiago,Sureda, Francesc X.,Mallol, Jordi,Lopez-Querol, Marta,Naesens, Lieve,Clercq, Erik De,Radhika Prathalingam,Kelly, John M.
scheme or table, p. 3198 - 3206 (2009/09/27)
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antivira
Easy synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones by silica gelpromoted fragmentation of 3-alkyl-2-oxaadamant-1-yl mesylates
Camps, Pelayo,El Achab, Rachid,Font-Bardia, Merce,Goerbig, Diana,Morral, Jordi,Munoz-Torrero, Diego,Solans, Xavier,Simon, Montserrat
, p. 5867 - 5880 (2007/10/03)
A synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones 4b-f and 4j,k by reaction of the corresponding 3-alkyl-2-oxaadamant-1-yl mesylates 3 with silica gel in methylene chloride at room temperature, is described. The method failed to give enones 4a,g and the
