16900-60-0

Basic information

• Product Name: 11-dodecynoic acid
• Synonyms: 11-dodecynoic acid
• CAS NO: 16900-60-0
• Molecular Formula: C12H20 O2
• Molecular Weight: 196.29
• Mol File: 16900-60-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 48°C (estimate)
• Boiling Point: 356.18°C (rough estimate)
• Flash Point: 149.8°C
• Appearance: /
• Density: 0.9746 (rough estimate)
• Vapor Pressure: 0.000137mmHg at 25°C
• Refractive Index: 1.4096 (estimate)
• CAS DataBase Reference: 11-dodecynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 11-dodecynoic acid(16900-60-0)
• EPA Substance Registry System: 11-dodecynoic acid(16900-60-0)

Safety Data

• Hazardous Substances Data: 16900-60-0(Hazardous Substances Data)

Usage

General Description

11-Dodecynoic acid is a long-chain carboxylic acid with a chemical formula C12H22O2. It is an unsaturated fatty acid with a terminal alkyne group that provides unique properties and reactivity. 11-Dodecynoic acid has been widely used in the field of organic synthesis and material science due to its potential as a versatile building block for the synthesis of various compounds with unique functional properties. Additionally, 11-Dodecynoic acid has been studied for its potential biological activities, including its antimicrobial and antitumor properties, making it an interesting compound for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C12H20O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h1H,3-11H2,(H,13,14)

Upstream product

• 65423-25-8 11-dodecenoic acid 
• 24567-43-9 11-dodecynoic acid methyl ester 
• 2777-65-3 undec-10-ynoic acid 
• 53163-99-8 11-oxoundecanoic acid 
• 21047-57-4 diethyl (1-diazo-2-oxopropyl)phosphonate 
• 7766-50-9 1-undecen-11-ylbromide 
• 50530-12-6 10-bromodecanoic acid 
• 95386-96-2 Acetic acid 11-cyano-undecyl ester 
• 73782-16-8 12-hydroxydodecanoic nitrile 
• 5810-18-4 11-cyanoundecanoic acid 
• 35042-91-2 11-cyanoundecanoyl chloride 
• 5048-44-2 11-dodecenenittrile 
• 947-05-7 oxacyclotridecan-2-one 
• 108545-36-4 12-(2-Nitro-phenylselanyl)-dodecanoic acid methyl ester 

Downstream Products

• 1351669-55-0 (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate 
• 1351669-57-2 (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate 
• 1351669-60-7 (S)-2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoic acid 
• 1351669-43-6 (3S,4S)-3-(dec-9-ynyl)-4-(3,4-dimethoxyphenetyl)oxetan-2-one 
• 1351669-61-8 (S)-methyl 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate 
• 2450-31-9 1,24-tetracosanedi acid 
• 24567-43-9 11-dodecynoic acid methyl ester 
• 19220-40-7 11-octadecynoic acid 
• 77159-57-0 15-hydroxy-11Z,13E-eicosadienoic acid 

Relevant articles and documents

SIMPLE SYNTHESIS OF 11-DODECYL ACID FROM CYCLODODECANONE

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INSULIN CONJUGATES

The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

A Sequential Homologation of Alkynes and Aldehydes for Chain Elongation with Optional 13C-Labeling

Terminal alkynes (RCCH) are homologated by a sequence of ruthenium-catalyzed anti-Markovnikov hydration of alkyne to aldehyde (RCH2CHO), followed by Bestmann-Ohira alkynylation of aldehyde to chain-elongated alkyne (RCH2CCH). Inverting the sequence by starting from aldehyde brings about the reciprocal homologation of aldehydes instead. The use of 13C-labeled Bestmann-Ohira reagent (dimethyl ((1-13C)-1-diazo-2-oxopropyl)phosphonate) for alkynylation provides straightforward access to singly or, through additional homologation, multiply 13C-labeled alkynes. The labeled alkynes serve as synthetic platform for accessing a multitude of specifically 13C-labeled products. Terminal alkynes with one or two 13C-labels in the alkyne unit have been submitted to alkyne-azide click reactions; the copper-catalyzed version (CuAAC) was found to display a regioselectivity of >50 000:1 for the 1,4- over the 1,5-triazine isomer, as shown analytically by 13C NMR spectroscopy.

17(R),18(S)-Epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analogues

17(R),18(S)-Epoxyeicosatetraenoic acid [17(R),18(S)-EETeTr], a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca 2+-overload with EC50 ≈ 1-2 nM. Structure-activity studies revealed that a cis-Δ11,12- or Δ14,15- olefin and a 17(R),18(S)-epoxide are minimal structural elements for antiarrhythmic activity whereas antagonist activity was often associated with the combination of a Δ14,15-olefin and a 17(S),18(R)-epoxide. Compared with natural material, the agonist and antagonist analogues are chemically and metabolically more robust and several show promise as templates for future development of clinical candidates.