169049-77-8

Upstream product

• 108310-92-5 2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate 

Downstream Products

• 233756-57-5 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester 
• 169049-78-9 3',5'-di-O-acetyl-2'-deoxy-N₂-{2-[(2,4-dinitrophenyl)amino]ethyl}-O₆-[2-(4-nitrophenyl)ethyl]guanosine 
• 233756-59-7 5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione 
• 233756-61-1 5-[(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-hydroxy-9H-purin-2-ylamino)-methyl]-1H-pyrimidine-2,4-dione 
• 233756-53-1 5-({9-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Nucleotides. Part LXXVIII: Double labeling of nucleosides and nucleotides

Several N(-hydroxyalkyl)-2,4-dinitroanilines were transformed into their phosphoramidites (see 5 and 6 in Scheme 1) in view of their use as fluorescence quenchers, and modified 2-aminobenzamides (see 9, 10, 18, and 19 in Scheme 1) were applied in model re

2’-DEOXYGUANOSINE HYBRID COMPOUND CONTAINING PYRROLE AMIDE TETRAMER, METHOD OF PRODUCING THE SAME AND PRODUCTION INTERMEDIATE THEREFOR

It is intended to provide an MGB polyamide hybrid compound which has a function of recognizing a base sequence useful in gene therapy, is efficacious in synthesizing an oligomer and has a high stability. An MGB polyamide hybrid compound represented by the following formula (38) which is characterized by being a pyrrole amide tetramer prepared by introducing a 1-methylpyrrole-2-carbonyl group as a substitute for the N-terminal formyl group in the existing case.

Design and synthesis of a new type of modified nucleoside for triple helix-mediated adenine-thymine base pair recognition: Formation of hydrogen bonds to the far-side adenine

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-T-X motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of triplex-forming modified nucleoside which are expected to act as DNA cleaving agents through the p-nitrophenyl group.

A high-yield synthesis of deoxy-2-fluoroinosine and its incorporation into oligonucleotides

An improved synthesis of the deoxy-2-fluoroinosine nucleoside is described, that makes use of mild fluorination (polyvinylpyridinium polyhydrogenfluoride) and O-silyl deprotection (triethylamine trihydrofluoride) reactions. The derived 5'-dimethoxytrityl-