169062-92-4 Usage
Uses
Used in Pharmaceutical Industry:
Cyclomarin A is used as a lead compound for the development of new antibiotics and antifungal agents due to its potent antibacterial and antifungal properties. Its ability to inhibit the growth of a wide range of bacteria, including drug-resistant strains, and its low toxicity to human cells make it a valuable asset in the fight against infectious diseases.
Used in Drug Development:
Cyclomarin A is used as a potential lead compound for the development of new pharmaceuticals to combat infectious diseases. Its unique structure and functional groups offer opportunities for further optimization and modification to enhance its therapeutic potential and target specific pathogens.
Used in Antimicrobial Research:
Cyclomarin A is used in antimicrobial research to study its mechanism of action and explore its potential as a novel antimicrobial agent. Understanding how it disrupts cell membrane integrity and exhibits antifungal activity can provide insights into the development of new strategies to combat drug-resistant bacteria and fungi.
Used in Drug Resistance Studies:
Cyclomarin A is used in drug resistance studies to investigate its effectiveness against drug-resistant strains of bacteria. Its ability to inhibit the growth of these strains can contribute to the development of new treatments for infections that are increasingly difficult to treat with existing antibiotics.
Check Digit Verification of cas no
The CAS Registry Mumber 169062-92-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,0,6 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 169062-92:
(8*1)+(7*6)+(6*9)+(5*0)+(4*6)+(3*2)+(2*9)+(1*2)=154
154 % 10 = 4
So 169062-92-4 is a valid CAS Registry Number.
169062-92-4Relevant articles and documents
Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity
Barbie, Philipp,Kazmaier, Uli
supporting information, p. 204 - 207 (2016/02/03)
An efficient synthetic protocol for the stereoselective synthesis of cyclomarin A is reported. Key steps in the syntheses of the building blocks are an asymmetric chelate-enolate Claisen rearrangement, an asymmetric hydrogenation, and highly diastereosele
Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities
Barbie, Philipp,Kazmaier, Uli
, p. 6036 - 6054 (2016/07/06)
Cyclomarins are cyclic heptapeptides containing four unusual amino acids. New synthetic protocols toward their synthesis have been developed, leading to the synthesis and biological evaluation of three natural occurring cyclomarins. Interestingly, cyclomarins address two completely different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), as well as PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.
