16907-49-6Relevant academic research and scientific papers
Process for producing aryl alpha-haloalkyl sulfones
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, (2008/06/13)
A process for preparing alkenes by reaction of various sulfone substrates with carbon tetrahalide in the presence of a strong base. The reactions are accelerated by the presence of a polar compound. Sulfone carbanions attack the carbon tetrahalide to produce an α-halogenated intermediate and a dihalocarbene. α-Halosulfones having α' hydrogens are converted to alkenes in situ via the Ramberg-Backland reaction. Sulfones having α but no α' hydrogens are simply α-halogenated. The dihalocarbene generated in the reaction may attack the product, solvent, or another substrate to form other products. Alkenes produced by reaction of carbon tetrahalides with di-sec-alkyl sulfones are readily attacked by dihalocarbene to form the alkene-dihalocarbene adduct (a substituted 1,1-dihalocyclopropane).
