1690854-69-3Relevant articles and documents
Synthesis of endolides A and B: Naturally occurring N-methylated cyclic tetrapeptides
Davison, Emma K.,Cameron, Alan J.,Harris, Paul W.R.,Brimble, Margaret A.
, p. 693 - 698 (2019)
Endolides A and B are naturally occurring, N-methylated, cyclic tetrapeptides possessing an unusual 3-(3-furyl)alanine amino acid and outstanding biological profiles. 1-Propanephosphonic anhydride (T3P) was used to mediate a solution-phase cyclisation reaction of the linear tetrapeptides, thus achieving the first syntheses of both endolides A and B. The stereoselectivity of the tetrapeptide cyclisation reactions was found to be reagent-controlled, and was independent of the C-terminal configuration of the linear peptide starting materials.
