169104-29-4Relevant academic research and scientific papers
Deamination of cyclaradine by adenosine deaminase under high pressure
Katagiri, Nobuya,Kokufuda, Hideaki,Makino, Masashi,Vince, Robert,Kaneko, Chikara
, p. 81 - 89 (2007/10/03)
The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure.
Biocatalytical Transformations- VI. The 4-Acetamido-cyclopent-2-ene Carboxylate Route Revisited: Synthesis of (+)- and (-)-Aristeromycin
Csuk, Rene,Doerr, Petra
, p. 5789 - 5798 (2007/10/02)
Enantiomerically pure (+)-as well as (-)-aristeromycin can be synthesized starting from (+)- or (-)-butyl (or hexyl) 4-acetamido-cyclopent-2-ene carboxylate; these carboxylates are easily obtained from their corresponding racemates by hydrolysis with the lipase from Candida rugosa.
Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
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, (2008/06/13)
The preparation of (±)-9-[α-(2α,3β-dihydroxy-4α-(hydroxymethyl) cyclopentyl)]-6-substituted purines: STR1 and (±)-3-[α-(2α, 3β-dihydroxy-4α-(hydroxymethyl)cyclopentyl)]-7-substituted-v-triazolo[4,5d]pyrimidines: STR2 and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: STR3 wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity.
