169104-86-3Relevant articles and documents
Synergizing combination having an antagonist effect on NKI and NK2 receptors
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, (2008/06/13)
Synergising associations characterized in that they are comprised of at least one product having an antagonist activity on NK1 receptors and at least one product having an antagonist activity on NK2 receptors. Said associations are useful in the treatment
Perhydroisoindole derivatives and preparation
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, (2008/06/13)
This ivention relates to novel perhydroisoindole derivatives having formula (I), STR1 wherein the symbols R, which are the same or different, are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical, R'' is a phenyl radical optionally 2-substituted by a C 1-2 alkylk or alkyloxy radical, R"" is a fluorine atom or a hydroxy radical, and R''"" is a hydrogen atom, or else R'' and R''"" are hydroxy radicals, or R"" and R''"" together form a bond, and R o is a hydrogen atom or a protective radical; salts thereof whereever applicable; and preparation thereof. These products are synthetic intermediates for the preparation of derivatives having P substance antagonist activity.
Isoindolone derivatives
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, (2008/06/13)
New isoindolone derivatives of general formula (I) are STR1 disclosed in which the radicals R represent hydrogen atoms or, together, form a bond, the symbol R' represents a hydrogen atom or a readily removable radical and the symbols R" are identical and