169141-01-9

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 169141-00-8 C₅₂H₅₀O₁₃ 
• 169140-99-2 5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid 

Downstream Products

• 178313-79-6 5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 1054621-74-7 5-{3-[Hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

A combinatorial protecting group strategy for oligonucleotide synthesis

A novel 5'-3' directed DNA synthesis will be described. Together with additional investigations on model compounds a synthetic strategy is established which allows multiselective deprotections. This offers the potential to either generate oligonucleotides in different sequence specific protection/functionalization states or to create a combinatorial set of molecules available for specific molecular interaction of recognition experiments.

A New Colorimetric Protecting Group Allowing Deprotection Under Neutral Conditions

A 4',4'-dimethoxytrityl derivative of the levulinyl group has been developed for protection of nucleophilic functionalities such as hydroxyl groups by reaction of its symmetrical anhydride.It can rapidly be removed under mild conditions using a hydrazine-pyridinium acetate based buffer at near neutral pH.This protecting group can be detected with high sensitivity at 513 nm (ε=78,600).