169157-99-7

Upstream product

• 169157-67-9 (S)-3-methoxycarbonylmethyl-2-oxopiperazine-1-acetic acid tert-butyl ester 
• 125218-33-9 (S)-2-((tert-butoxycarbonyl)amino)-3-(3-fluoro-4-hydroxyphenyl)propanoic acid (N-Boc-3-fluorotyrosine) 
• 340732-95-8 {1-[2-tert-butoxycarbonylamino-3-(3-fluoro-4-hydroxy-phenyl)-propionyl]-4-tert-butoxycarbonylmethyl-3-oxo-piperazin-2-yl}-acetic acid methyl ester 

Relevant academic research and scientific papers

Novel non-peptide GPIIb/IIIa antagonists: Synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2- oxoethyl)-2-oxopiperazinyl] acetic acids

To improve the in vitro and in vivo potency of our first low molecular weight GPIIb/IIIa antagonist 1 (TAK-029), a series of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2- oxoethyl)-2-oxopiperazinyl]acetic acids were synthesized th