169176-73-2Relevant academic research and scientific papers
Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids
Shimada, Naoyuki,Takahashi, Naoya,Ohse, Naoki,Koshizuka, Masayoshi,Makino, Kazuishi
supporting information, p. 13145 - 13148 (2020/11/09)
The first successful example of the direct synthesis of Weinreb amides using catalytic hydroxy-directed dehydrative amidation of carboxylic acids using the diboronic acid anhydride catalyst is described. The methodology is applicable to the concise syntheses of eight α-hydroxyketone natural products, namely, sattabacin, 4-hydroxy sattabacin, kurasoins A and B, soraphinols A and B, and circumcins B and C.
Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus
Huang, Sheng-Xiong,Powell, Emily,Rajski, Scott R.,Zhao, Li-Xing,Jiang, Cheng-Lin,Duan, Yanwen,Xu, Wei,Shen, Ben
supporting information; experimental part, p. 3525 - 3527 (2010/10/02)
(Equation Presented). Estrogen receptor ERα and ERβ heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutil
Concise, protecting group free total syntheses of (+)-sattabacin and (+)-4-hydroxysattabacin
Aronoff, Matthew R.,Bourjaily, Neil A.,Miller, Kenneth A.
supporting information; experimental part, p. 6375 - 6377 (2011/01/03)
The first asymmetric total syntheses of the antiviral natural products (+)-sattabacin and (+)-4-hydroxysattabacin are reported. Both total syntheses are remarkably concise and were completed without the use of protecting groups. These syntheses allowed the unambiguous assignment of the absolute configuration of both natural products. The syntheses of these natural products, which exhibit marked antiviral activity, are readily amenable to the preparation of structural analogs and progress in this regard is also reported.
