169188-17-4

Basic information

• Product Name: 4-(2-Nitrophenyl)benzaldehyde
• Synonyms: 4-(2-Nitrophenyl)benzaldehyde;2'-Nitro-biphenyl-4-carboxaldehyde
• CAS NO: 169188-17-4
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.22
• Mol File: 169188-17-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 389.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.274±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(2-Nitrophenyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Nitrophenyl)benzaldehyde(169188-17-4)
• EPA Substance Registry System: 4-(2-Nitrophenyl)benzaldehyde(169188-17-4)

Safety Data

• Hazardous Substances Data: 169188-17-4(Hazardous Substances Data)

Usage

General Description

4-(2-nitrophenyl)benzaldehyde is a chemical compound with the molecular formula C13H9NO3. It is a yellow crystalline solid that is commonly used in organic synthesis and as a reagent in various chemical reactions. 4-(2-Nitrophenyl)benzaldehyde is known for its aromatic and aldehyde functional groups, making it suitable for applications in the production of dyes, pharmaceuticals, and other organic compounds. 4-(2-nitrophenyl)benzaldehyde is also used as a precursor in the synthesis of various organic compounds due to its versatile reactivity and ability to form complex molecular structures. However, it should be handled with care due to its potential hazards, including its toxic and irritant properties.

Upstream product

• 87199-17-5 4-formylphenylboronic acid, 
• 552-16-9 ortho-nitrobenzoic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 15163-59-4 potassium o-nitrobenzoate 
• 5570-19-4 2-nitrophenylboronic acid 
• 88-73-3 2-Chloronitrobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 114772-39-3 4'-bromomethyl-2-nitrobiphenyl 
• 577-19-5 2-nitrophenyl bromide 
• 3218-36-8 4-Phenylbenzaldehyde 
• 56-23-5 tetrachloromethane 
• 70680-21-6 4-methyl-2'-nitrobiphenyl 

Downstream Products

• 99585-18-9 9H-carbazole-2-carboxaldehyde 
• 885280-30-8 4-(amino phenyl) phenyl methanone 

Relevant articles and documents

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Visible-light-driven Cadogan reaction

Visible-light-driven photochemical Cadogan-type cyclization has been discovered. The organic D-A type photosensitizer 4CzIPN found to be an efficient mediator to transfer energy from photons to the transient intermediate that breaks the barriers of deoxygenation in Cadogan reaction and enables a mild metal-free access to carbazoles and related heterocycles. DFT calculation results indicate mildly endergonic formation of the intermediate complex of nitrobiarenes and PPh3, which corresponds with experimental findings regarding reaction temperature. The robust synthetic capacity of the photoredox Cadogan reaction systems has been demonstrated by the viable productivity of a broad range of carbazoles and related N-heterocycles with good tolerance of various functionalities.

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

Human rhinoviruses (HRV) are the predominant cause of common colds and flu-like illnesses, but are also responsible for virus-induced exacerbations of asthma and chronic obstructive pulmonary disease. However, to date, no drug has been approved yet for clinical use. In this study, we present the results of the structure-based lead optimization of a class of new small-molecule inhibitors that we previously reported to bind into the pocket beneath the canyon of the VP1 protein. A small series of analogues that we designed based on the available structure and interaction data were synthesized and evaluated for their potency to inhibit the replication of HRV serotype 14. 2-(4,5-Dimethoxy-2-nitrophenyl)-1-(4-(pyridin-4-yl)phenyl)ethanol (3v) was found to be a potent inhibitor exhibiting micromolar activity (EC50 Combining double low line 3.4 ± 1.0 μM) with a toxicity for HeLa cells that was significantly lower than that of our previous hit (LPCRW-0005, CC50 Combining double low line 104.0 ± 22.2 μM; 3v, CC50 > 263 μM).