169203-64-9

Upstream product

• 51436-99-8 2-fluoro-4-bromotoluene 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 

Downstream Products

• 1027930-49-9 1-[3-(4-Bromo-2-fluoro-benzyl)-5-ethyl-2-propyl-3H-imidazol-4-yl]-prop-2-en-1-ol 
• 1027892-76-7 N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide 
• 1026289-75-7 N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide 
• 1025972-75-1 N-{3-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-phenyl-isonicotinamide 
• 1027138-71-1 N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-phenyl-isonicotinamide 
• 167266-29-7 N-{3-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-phenyl-benzamide 
• 167266-30-0 N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-phenyl-benzamide 
• 1027074-21-0 N-{3-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-propionamide 
• 1026297-21-1 N-{3-[3-(2'-tert-Butylsulfamoyl-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide 
• 1028299-71-9 N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-2-yl-nicotinamide 

Relevant academic research and scientific papers

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3- amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors

The identification of the AT1 and AT2 receptor subtypes has stimulated interest in developing balanced angiotensin II receptor antagonists. A series of 5-(3-amidopropanoyl)imidazoles has been prepared which possess balanced affinity for the AT1 and AT2 receptors. XR510 (1), 1-[[2'- [[(isopentoxycarbonyl)amino]sulfonyl]-3-fluoro(1,1'-biphenyl)-4-yl]methyl]- 5-[3-(N-pyridin-3-ylbutanamido)propanoyl]-4-ethyl-2-propyl-1H-imidazole, potassium salt, exhibits subnanomolar affinity for both receptor sites. XR510 is very active in lowering blood pressure in renal hypertensive rats and furosemide-treated dogs following oral administration.

Imidazole 5-position substituted angiotensin II antagonists

Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: STR1 These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)methyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents.