169228-07-3

Upstream product

• 55130-67-1 6-methyl-5-(4-nitrobenzoyl)-2(1H)-pyridinone 

Downstream Products

• 169228-11-9 3-bromo-5-(4-hydroxyphenyl)-1,6-naphthyridin-2-amine 
• 169228-25-5 5-(4-hydroxyphenyl)-3-bromo-1,6-naphthyridin-2(1H)-one 
• 169228-24-4 3-bromo-5-(4-aminophenyl)-1,6-naphthyridin-2(1H)-one 

Relevant academic research and scientific papers

Novel and potent adenosine 3',5'-cyclic phosphate phosphodiesterase III inhibitors: Thiazolo[4,5-b][1,6]naphthyridin-2-ones

The transformation of 3-bromo-1,6-naphthyridin-2(1H)-ones 8 to thiazolo[4,5-b][1,6]naphthyridin-2(1H)-ones 12 resulted in a 2-9-fold increase in cAMP phosphodiesterase (PDE) III inhibitory potency. Unlike the secondary binding sites on the cAMP PDE III is