169237-15-4Relevant academic research and scientific papers
A versatile catalyst for heck reactions of aryl chlorides and aryl bromides under mild conditions
Littke,Fu
, p. 6989 - 7000 (2007/10/03)
In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono- and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron-neutral and electron-rich aryl chlorides proceed at elevated temperature, also with high selectivity. In terms of scope and mildness, Pd/P(t-Bu)3/Cy2NMe represents an advance over previously reported catalysts for these Heck coupling processes.
A Stereoselective Route to the Sugar-Cinnamate Unit of Hygromycin A
Buchanan, J. Grant,Hill, David G.,Wightman, Richard H.,Boddy, Ian K.,Hewitt, Brian D.
, p. 6033 - 6050 (2007/10/02)
Various aryl 6-deoxy-5-keto-β-D-arabino-hexofuranosides, including one (42) corresponding to the sugar-cinnamate unit of Hygromycin A (1) have been synthesized by a method in which 6-deoxy-β-D-glucofuranosides are first prepared, followed by configuration
