169252-51-1Relevant articles and documents
Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity
Cutrona, Kara J.,Miller, Scott J.,Stone, Elizabeth A.
, p. 12690 - 12698 (2020)
Analogues of the conformationally dynamic Claritin (loratadine) and Clarinex (desloratadine) scaffolds have been enantio- and chemoselectively N-oxidized using an aspartic acid containing peptide catalyst to afford stable, helically chiral products in up