169259-87-4Relevant academic research and scientific papers
Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells
Chen, Jinying,Ma, Liang,Zhang, Ronghong,Tang, Jie,Lai, Huijun,Wang, Jun,Wang, Guangcheng,Xu, Qinyuan,Chen, Tao,Peng, Fei,Qiu, Jingxiang,Liang, Xiaolin,Cao, Dong,Ran, Yan,Peng, Aihua,Wei, Yuquan,Chen, Lijuan
, p. 945 - 956 (2013/02/22)
A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin congeners were synthesized by employing click chemistry and further evaluated for their antitumor activity by MTT assay. Among them, six congeners (10, 11, 12, 13, 22, and 24) exhibited ap
Copper(I) iodide: A catalyst for the improved synthesis of aryl propargyl ethers
Bell,Davies,Geen,Mann
, p. 707 - 712 (2007/10/02)
Copper(I) iodide catalyses the reaction between phenols and dialkylpropargyl chlorides to give aryl 1,1-dialkylpropargyl ethers 5 a-k and 7a-e in good yields and purity. These ethers are important as precursors to the 2H-1-benzopyrans 8a-l and 9a-e.
Variation in the aromatic ring of cromakalim: Antihypertensive activity of pyranopyridines and 6-alkyl-2H-1-benzopyrans
Burrell,Cassidy,Evans,Lightowler,Stemp
, p. 3023 - 3027 (2007/10/02)
The synthesis and antihypertensive activity in the spontaneously hypertensive rat of two new series of analogues related to cromakalim (1) are described. In the first series, where the benzopyran nucleus has been replaced by a pyranopyridine nucleus, the
