169268-97-7Relevant academic research and scientific papers
Aza-heterocycles via copper-catalyzed, remote C–H desaturation of amines
Dare, Ross M.,Nagib, David A.,Paneque, Alyson N.,Stateman, Leah M.
supporting information, p. 210 - 224 (2022/01/19)
A majority of medicines contain a nitrogen atom within a five- or six-membered ring. To rapidly access both such aza-heterocycles, we sought to develop a remote C–H desaturation of amines. Inspired by the Hofmann-L?ffler-Freytag (HLF) synthesis of five-me
Use of aryl chlorides as electrophiles in Pd-catalyzed alkene difunctionalization reactions
Rosen, Brandon R.,Ney, Joshua E.,Wolfe, John P.
supporting information; experimental part, p. 2756 - 2759 (2010/07/08)
The development of conditions that allow use of inexpensive aryl chlorides as electrophiles in Pd-catalyzed alkene carboamination and carboetherification reactions is described. A catalyst composed of Pd(OAc)2 and S-Phos minimizes N-arylation of the substrate and prevents formation of mixtures of regioisomeric products. A number of heterocycles, including pyrrolidines, isoxazolidines, tetrahydrofurans, and pyrazolidines, are efficiently generated with this method.
N-t-butoxycarbonyl protection of primary and secondary amines in the hydroboration reaction: Synthesis of amino alcohols
Kabalka,Li,Pace
, p. 2135 - 2143 (2007/10/02)
The use of the BOC group as a protecting group in the hydroboration of aminoalkenes is described. The isolated yields of amino alcohols via the hydroboration-oxidation sequence are excellent.
