169274-78-6

Basic information

• Product Name: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE
• Synonyms: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE;RO 25-6981 MALEATE;(alpha-R,beta-S)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate;Ro 25-6981 maleate salt;(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate;(aR,bS)-a-(4-Hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate;(alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol
• CAS NO: 169274-78-6
• Molecular Formula: C26H33NO6
• Molecular Weight: 455.54
• Product Categories: Glutamate
• Mol File: 169274-78-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 703.7°Cat760mmHg
• Flash Point: 379.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.52E-11mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Desiccate at RT
• PKA: 10.01±0.26(Predicted)
• CAS DataBase Reference: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE(CAS DataBase Reference)
• NIST Chemistry Reference: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE(169274-78-6)
• EPA Substance Registry System: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE(169274-78-6)

Safety Data

• Hazardous Substances Data: 169274-78-6(Hazardous Substances Data)

Usage

Uses

Ro 25-6981 maleate is a potent NMDA receptor antagonist.

Biological Activity

Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC 50 values are 0.009 and 52 μ M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro .

InChI:InChI=1/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1