169287-77-8 Usage
General Description
BOC-PNA-G(Z)-OH is a chemical compound that consists of a peptide nucleic acid (PNA) monomer with a BOC protecting group on the N-terminus, a guanine base (G), and a Z protecting group on the C-terminus. PNA is a synthetic nucleic acid mimic that is designed to bind to complementary DNA or RNA sequences with high affinity and specificity. The BOC protecting group is used to temporarily block the reactive amine on the N-terminus, while the Z protecting group provides stability to the C-terminus. BOC-PNA-G(Z)-OH has applications in nucleic acid research, diagnostics, and therapeutics, particularly in the development of antisense oligonucleotides and molecular probes for detecting specific DNA or RNA sequences.
Check Digit Verification of cas no
The CAS Registry Mumber 169287-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,2,8 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169287-77:
(8*1)+(7*6)+(6*9)+(5*2)+(4*8)+(3*7)+(2*7)+(1*7)=188
188 % 10 = 8
So 169287-77-8 is a valid CAS Registry Number.
169287-77-8Relevant articles and documents
A convergent strategy for the modification of peptide nucleic acids: Novel mismatch-specific PNA-hybridization probes
Seitz, Oliver,Bergmann, Frank,Heindl, Dieter
, p. 2203 - 2206 (1999)
Coupling of nonnatural nucleobases to the orthogonally protected backbone 1 on the solid phase provided access to novel peptide nucleic acid (PNA) conjugates 2, which are difficult to synthesize by standard routes. Hybridization probes containing the thia