169295-45-8

Upstream product

• 598-26-5 dimethylketene 
• 60-29-7 diethyl ether 
• 164917-45-7 3-(2,5-Dimethylphenoxy)-propionaldehyde 
• 95-87-4 2,5-Dimethylphenol 

Downstream Products

• 25812-30-0 gemfibrozil 

Relevant academic research and scientific papers

Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids

Novel 3-substituted derivatives of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids of formula (I) are prepared. These compouds are prepared from 2,2-dimethyl-5-substituted phenoxy-3-hydroxy-pentanoic acid-β-lactones (formula II). The β-lactones are prepared by condensing relevant phenoxypropanals with dimethylketene.

A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

A new synthesis of antihyperlipoproteinemic agent 2,2-dimethyl-5-(2,5-dimethylphenoxy) pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β-lactone 6, prepared from cycloaddition of 3-(2,5-dimethylphenoxy) propanal with dimethylketene.The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industral scale of production.Key Words Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; Dimethylketene; cycloaddition; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone.