169318-10-9Relevant academic research and scientific papers
Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure
Gossett, Lynn S.,Habeck, Lillian L.,Gates, Susan B.,Andis, Sherri L.,Worzalla, John F.,Schultz, Richard M.,Mendelsohn, Laurane G.,Kohler, William,Ratnam, Manohar,Grindey, Gerald B.,Shih, Chuan
, p. 473 - 476 (2007/10/03)
A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a
