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169332-61-0

AC-DEVD-AMC, also known as N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin, is a synthetic peptide substrate that is widely used in the assessment of caspase-3 activity. It is a fluorogenic substrate, meaning that it emits fluorescence upon cleavage by caspase-3, allowing for the quantification of enzyme activity. AC-DEVD-AMC is a valuable tool in research settings for studying the mechanisms of apoptosis and the effects of various compounds on caspase-3 activity.

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  • L-a-Asparagine, N-acetyl-L-a-aspartyl-L-a-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

    Cas No: 169332-61-0

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  • 169332-61-0 Structure

  • Basic information

    1. Product Name: AC-DEVD-AMC
    2. Synonyms: N-ACETYL-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN AMC;AC-ASP-MET-GLN-ASP-AMC;AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN;AC-ASP-GLU-VAL-ASP-MCA;AC-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN;AC-ASP-GLU-VAL-ASP-AMC;AC-ASP-GLU-VAL-ASP-AMC AMMONIUM SALT;AC-DEVD-AMC
    3. CAS NO:169332-61-0
    4. Molecular Formula: C30H37N5O13
    5. Molecular Weight: 675.64
    6. EINECS: N/A
    7. Product Categories: peptide;Pepetides
    8. Mol File: 169332-61-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 1200.1 °C at 760 mmHg
    3. Flash Point: 679.6 °C
    4. Appearance: white/powder
    5. Density: 1.423 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: DMSO: 10 mM
    9. PKA: 4.09±0.10(Predicted)
    10. CAS DataBase Reference: AC-DEVD-AMC(CAS DataBase Reference)
    11. NIST Chemistry Reference: AC-DEVD-AMC(169332-61-0)
    12. EPA Substance Registry System: AC-DEVD-AMC(169332-61-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 169332-61-0(Hazardous Substances Data)

169332-61-0 Usage

Uses

Used in Biomedical Research:
AC-DEVD-AMC is used as a substrate for caspase-3 assay in various cell types, including human colon cancer cell lines and bone marrow mesenchymal stem cells. The reason for its use in these applications is to evaluate the activity of caspase-3, a key enzyme involved in the execution of apoptosis, which is crucial for understanding the mechanisms of cell death and the potential therapeutic effects of compounds on apoptosis regulation.

Biochem/physiol Actions

Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Check Digit Verification of cas no

The CAS Registry Mumber 169332-61-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,3,3 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 169332-61:
(8*1)+(7*6)+(6*9)+(5*3)+(4*3)+(3*2)+(2*6)+(1*1)=150
150 % 10 = 0
So 169332-61-0 is a valid CAS Registry Number.

169332-61-0 Well-known Company Product Price

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  • Sigma

  • (A1086)  N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin  ≥97% (HPLC), powder

  • 169332-61-0

  • A1086-5MG

  • 3,952.26CNY

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