16935-06-1

Basic information

• Product Name: 1H-Imidazole-1-propanoic acid, 2-methyl-4-nitro-, methyl ester
• CAS NO: 16935-06-1
• Molecular Formula: C8H11N3O4
• Mol File: 16935-06-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-propanoic acid, 2-methyl-4-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-propanoic acid, 2-methyl-4-nitro-, methyl ester(16935-06-1)
• EPA Substance Registry System: 1H-Imidazole-1-propanoic acid, 2-methyl-4-nitro-, methyl ester(16935-06-1)

Safety Data

• Hazardous Substances Data: 16935-06-1(Hazardous Substances Data)

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 

Downstream Products

• 328056-88-8 3-(2-methyl-4-nitroimidazol-1-yl)-propionylhydrazine 
• 139975-79-4 methyl 3-(5-bromo-2-methyl-4-nitro-1H-imidazol-1-yl)propanoate 

Relevant articles and documents

Promiscuous acylase-catalyzed aza-Michael additions of aromatic N-heterocycles in organic solvent

A novel and efficient enzymatic promiscuous protocol for aza-Michael addition of aromatic N-heterocycles to α,β-unsaturated compounds has been described. The reactions were catalyzed by promiscuous zinc-active-site acylase in organic solvent at 50 °C. The strategy works with a broad range of N-heterocycles to afford the corresponding Michael adduct with good yields in several hours (0.5-6 h). This catalytic promiscuity is the first example of metal-active-site enzyme-catalyzed aza-Michael addition for aromatic N-heterocycles.

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL im from: Thermomyces lanuginosus in a continuous flow microreactor

A fast and green protocol for the Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor was developed. In contrast with existing methods, this method is simple (35 min), uses mild reaction conditions (45 °C) and is environmentally friendly. This enzymatic Michael addition performed in continuous flow microreactors is an innovation that may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

N-Methylimidazole as a promising catalyst for the aza-Michael addition reaction of N-heterocycles

N-Methylimidazole has been shown to be a promising catalyst for aza-Michael reactions. Various N-heterocycles were introduced to α,β-unsaturated carbonyl compounds employing N-methylimidazole (0.05 equiv) in a highly efficient, rapid and high yielding syn

A fast and highly efficient protocol for Michael addition of N-heterocycles to α,β-unsaturated compound using basic ionic liquid [bmIm]OH as catalyst and green solvent

A fast and green protocol for the Michael addition of N-heterocycles to α,β-unsaturated compounds at room temperature was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, as a catalyst and a reaction medium. The react