1693766-04-9

Basic information

• Product Name: 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone
• Synonyms: 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone;GSK-8573(negative control of GSK-2801)
• CAS NO: 1693766-04-9
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.38564
• EINECS: -0
• Mol File: 1693766-04-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone(1693766-04-9)
• EPA Substance Registry System: 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone(1693766-04-9)

Safety Data

• Hazardous Substances Data: 1693766-04-9(Hazardous Substances Data)

Usage

Description

1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone is a complex organic chemical compound that features a ketone group along with a 3-methoxyphenyl and a 7-propoxyindolizin-3-yl group. Its intricate molecular structure endows it with unique properties that make it a candidate of interest in pharmaceutical research and drug development.

Uses

Used in Pharmaceutical Research:
1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone is used as a research compound for exploring its potential biological activities and therapeutic effects. Its unique structure may offer novel avenues for the development of new drugs.
Used in Drug Development:
In the field of drug development, 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone is utilized as a lead compound. It may serve as a starting point for the synthesis of new pharmaceutical agents, given its distinctive chemical features that could interact with biological targets in innovative ways.
Used in Chemical Synthesis:
1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone may also be used as an intermediate in the synthesis of other complex organic molecules, particularly in the pharmaceutical and chemical industries, where its specific functional groups can be further modified to create a variety of derivatives with different applications.

Upstream product

• 10365-98-7 3-methoxyphenylboronic acid 
• 75124-98-0 4-propoxypyridine 
• 7379-35-3 4-chlorpyridine hydrochloride 

Relevant articles and documents

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Bromodomains are acetyl-lysine specific protein interaction domains that have recently emerged as a new target class for the development of inhibitors that modulate gene transcription. The two closely related bromodomain containing proteins BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the expression of noncoding RNAs. However, BAZ2 bromodomains have low predicted druggability and so far no selective inhibitors have been published. Here we report the development of GSK2801, a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains as well as the inactive control compound GSK8573. GSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures demonstrated a canonical acetyl-lysine competitive binding mode. Cellular activity was demonstrated using fluorescent recovery after photobleaching (FRAP) monitoring displacement of GFP-BAZ2A from acetylated chromatin. A pharmacokinetic study in mice showed that GSK2801 had reasonable in vivo exposure after oral dosing, with modest clearance and reasonable plasma stability. Thus, GSK2801 represents a versatile tool compound for cellular and in vivo studies to understand the role of BAZ2 bromodomains in chromatin biology.