169378-11-4Relevant academic research and scientific papers
Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof
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, (2008/06/13)
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.
Novel NMDA Antagonists: Replacement of the Pyridinium Ring of 6,11-Ethanobenzoquinolizinium Cations with Heteroisoquinolinium Cations
Kumar, Virendra,Carbateas, Phil M.,Dority, John A.,Earley, William G.,Mallamo, John P.,et al.
, p. 1826 - 1830 (2007/10/02)
Replacement of the pyridinium ring of 6,11-ethanobenzoquinolizinium cations with thiazolium (4a and 4b) and N-methylimidazolium (4c and 4d) resulted in equipotent compounds in the TCP binding assay.The corresponding N-methyl-1,2,4-triazolium analogs were less potent in this assay.The thiazolium derivative 4b, with a Ki = 2.9 nM, is being evaluated as a possible neuroprotective N-methyl-D-aspartic acid (NMDA) anatgonist.
