169447-86-3 Usage
Description
(S)-1-Boc-2-benzylpiperazine, a chemical compound with the molecular formula C18H26N2O2, is a derivative of piperazine featuring a Boc (tert-butoxycarbonyl) protecting group at the N1 position and a benzyl group at the N2 position. (S)-1-Boc-2-benzylpiperazine is characterized by its role in the synthesis of pharmaceutical and biologically active molecules, as well as its potential in medicinal chemistry and drug discovery due to its favorable pharmacokinetic and pharmacodynamic properties.
Uses
Used in Organic Synthesis:
(S)-1-Boc-2-benzylpiperazine is used as a building block in organic synthesis for the preparation of various pharmaceutical and biologically active molecules. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-1-Boc-2-benzylpiperazine is used as a precursor in the synthesis of drugs targeting the central nervous system, such as antidepressants and antipsychotics. Its structural features contribute to the development of medications that can effectively address mental health disorders.
Used in Medicinal Chemistry and Drug Discovery:
(S)-1-Boc-2-benzylpiperazine is utilized in medicinal chemistry and drug discovery due to its favorable pharmacokinetic and pharmacodynamic properties. Its potential applications in these fields highlight its importance in the development of novel therapeutic agents and the advancement of medical research.
Check Digit Verification of cas no
The CAS Registry Mumber 169447-86-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,4,4 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 169447-86:
(8*1)+(7*6)+(6*9)+(5*4)+(4*4)+(3*7)+(2*8)+(1*6)=183
183 % 10 = 3
So 169447-86-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)18-10-9-17-12-14(18)11-13-7-5-4-6-8-13/h4-8,14,17H,9-12H2,1-3H3/t14-/m0/s1
169447-86-3Relevant articles and documents
Efficient one-pot synthesis of enantiomerically pure: N -protected-α-substituted piperazines from readily available α-amino acids
Jida, Mouhamad,Ballet, Steven
, p. 1595 - 1599 (2018/02/09)
A new pathway towards enantiomerically pure 3-substituted piperazines, bearing a benzyl protecting group, has been developed in good overall yields (83-92%), starting from commercially available N-protected amino acids. The methodology represents an efficient and simple one-pot procedure, employing a synthetic sequence consisting of an Ugi-4 component reaction, a Boc-deprotection, an intramolecular cyclisation reaction and a final reduction (UDCR). From the benzyl protected precursors, the 2-substituted piperazines bearing a Boc-protecting group could consequently also be obtained via a simple protection and deprotection step of the corresponding piperazines. The practical utility of this methodology was demonstrated for chiral drug synthesis.
Inhibitors of farnesyl-protein transferase
-
, (2008/06/13)
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. The compounds of formula A are representative of the compounds of the present invention: STR1