16946-91-1Relevant academic research and scientific papers
Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation
Koshizuka, Masayoshi,Makino, Kazuishi,Shimada, Naoyuki
supporting information, (2020/11/03)
We report the catalytic direct peptide bond formations via dehydrative condensation of β-hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, and excellent chemoselectivity. The key to the success of these atom-economical transformations is the use of diboronic acid anhydride catalyst for the hydroxy-directed reactions.
Highly efficient and versatile synthesis of proteoglycan core structures from 1,6-anhydro-β-lactose as a key starting material
Shimawaki, Ken,Fujisawa, Yoshinori,Sato, Fumihiro,Fujitani, Naoki,Kurogochi, Masaki,Hoshi, Hiroko,Hinou, Hiroshi,Nishimura, Shin-Ichiro
, p. 3074 - 3079 (2008/03/18)
Versatile building blocks in the form of novel derivatives of 1,6-anhydro-β-lactose have been used for the rapid and highly efficient synthesis of various proteoglycan core structures (see example). The resulting oligosaccharide-tetrapeptide conjugates ca
