169464-88-4Relevant articles and documents
An Electrophilic Approach to the Palladium-Catalyzed Carbonylative C-H Functionalization of Heterocycles
Tjutrins, Jevgenijs,Arndtsen, Bruce A.
, p. 12050 - 12054 (2015)
A palladium-catalyzed approach to intermolecular carbonylative C-H functionalization is described. This transformation is mediated by PtBu3-coordinated palladium catalyst and allows the derivatization of a diverse range of heterocycles, including pyrroles, indoles, imidazoles, benzoxazoles, and furans. Preliminary studies suggest that this reaction may proceed via the catalytic formation of highly electrophilic intermediates. Overall, this provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones using stable reagents (aryl iodides and CO) and without the typical need to exploit pre-metalated heterocycles in carbonylative coupling chemistry.
ANXIOLYTIC AROYL PIPERIDINYL AND PIPERAZINYLACYL PYRROLES
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, (2008/06/13)
Aroyl(piperidinyl and piperazinyl)acyl pyrroles of the following formula have anxiolytic activity: STR1 wherein, Y is selected from the group consisting of N, CH or COH;A. sup.1 is selected from the group consisting of STR2 n is an integer from 1 to