169495-51-6

Basic information

• Product Name: ethyl2-aMino-5-chloronicotinate
• Synonyms: Ethyl 2-aMino-5-chloropyridine-3-carboxylate;2-Amino-5-chloro-3-pyridinecarboxylic acid ethyl ester;ethyl2-aMino-5-chloronicotite
• CAS NO: 169495-51-6
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 201
• Mol File: 169495-51-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 298.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.326±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.61±0.49(Predicted)
• CAS DataBase Reference: ethyl2-aMino-5-chloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl2-aMino-5-chloronicotinate(169495-51-6)
• EPA Substance Registry System: ethyl2-aMino-5-chloronicotinate(169495-51-6)

Safety Data

• Hazardous Substances Data: 169495-51-6(Hazardous Substances Data)

Usage

General Description

Ethyl 2-amino-5-chloronicotinate is a chemical compound with the formula C8H8ClNO2. It is an organic compound that consists of a nicotinic acid derivative with an ethyl group attached to the amino group at the 2-position and a chlorine atom at the 5-position. ethyl2-aMino-5-chloronicotinate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs due to its pharmacological properties, and it is also used as a precursor in the synthesis of various heterocyclic compounds. Additionally, its chemical structure makes it a useful tool in medicinal chemistry research for the development of new therapeutic agents.

Upstream product

• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 7722-84-1 dihydrogen peroxide 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 181123-22-8 ethyl 2-amido-(N-phenylacetyl)-5-chloronicotinate 
• 181123-23-9 ethyl 2-amido-[N-(3-phenoxy)phenylacetyl]-5-chloronicotinate 

Relevant articles and documents

Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles

We studied the cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that are not easily accessed by conventional methods. The strategy addressed some structural diversity issues currently facing medicinal chemistry, and the resulting pyridines could be used as convenient precursors for the synthesis of related pharmaceuticals. In particular, our method was applied to the syntheses of the marketed drug etoricoxib and several biologically important molecules in a few steps.

NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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AZA AND AZA (N-OXY) ANALOGS OF GLYCINE/NMDA RECEPTOR ANTAGONISTS

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