1695112-92-5

Basic information

• Product Name: (1R,4R)-(4-CyclopropylaMino-cyclohexyl)-carbaMic acid tert-butyl ester
• Synonyms: tert-Butyl((1r,4r)-4-(cyclopropylamino)cyclohexyl)carbamate;(1R,4R)-(4-Cyclopropylamino-cyclohexyi)-carbamic acid tert-butyl ester;(1R,4R)-(4-CyclopropylaMino-cyclohexyl)-carbaMic acid tert-butyl ester
• CAS NO: 1695112-92-5
• Molecular Formula: C14H26N2O2
• Molecular Weight: 254.37
• Mol File: 1695112-92-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1R,4R)-(4-CyclopropylaMino-cyclohexyl)-carbaMic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4R)-(4-CyclopropylaMino-cyclohexyl)-carbaMic acid tert-butyl ester(1695112-92-5)
• EPA Substance Registry System: (1R,4R)-(4-CyclopropylaMino-cyclohexyl)-carbaMic acid tert-butyl ester(1695112-92-5)

Safety Data

• Hazardous Substances Data: 1695112-92-5(Hazardous Substances Data)

Relevant articles and documents

Solid dispersions containing an apoptosis-inducing agent

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.