169515-33-7

Upstream product

• 169515-32-6 C₄₆H₅₁N₄O₁₅P 
• 552-89-6 2-nitro-benzaldehyde 
• 78635-98-0 3'-O-levulinoylthymidine 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 

Downstream Products

• 199733-68-1 C₇₁H₉₄N₅O₁₈PSi 
• 199733-69-2 C₆₆H₈₈N₅O₁₆PSi 

Relevant academic research and scientific papers

Synthesis of 3',5'-dithymidylyl-α-hydroxyphosphonate dimer building blocks for oligonucleotide synthesis - A new pro-oligonucleotide approach

The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)15-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T(m) values) were examined.

Synthesis of protected 3',5'-di-2'-deoxythymidine-(α-hydroxy-2- nitrobenzyl)-phosphonate diesters as dimer building blocks for oligonucleotides

The synthesis of 3'-succinyl-CPG bound 3',5'-di-2'-deoxythymidyl-(α- hydroxy-2-nitrobenzyl)-phosphonate diester 1 and the 3'-phosphoamidite derivative 2 is described. The hydroxyl-groups of the backbone modification were protected with trialkylsilyl group